Yaohai Novagen recently announced the official launch of a major new product: Novi Orea Recombinant Collagen Freeze-Dried Fibers. Featuring the distinctive advantages of 100% humanized type III collagen, the product introduces a new option for anti-aging care in medical aesthetics.

01

Targeting the Root Cause and Rebuilding the Collagen Network

Data show that skin begins to age gradually after the age of 20, with total collagen declining by approximately 1% each year. By age 40, more than half of the skin’s collagen may already be lost. Collagen depletion is a fundamental cause of wrinkles, depressions, and skin laxity.

The collagen types most responsible for maintaining youthful skin are types I and III. Type III accounts for 10%–15% and forms a loose mesh that provides elasticity, supports repair and healing, and plays a key role in scarless healing in infants. Type I accounts for 80%–85% and forms thick bundles that provide the skin’s structural framework, firmness, and resilience.

After application, Novi Orea Recombinant Humanized Type III Collagen Freeze-Dried Fibers can form a collagen fiber network. This mesh-like structure supports cells and tissues and provides favorable cell adhesion, allowing cells to grow in an orderly manner along the network and supporting tissue repair, regeneration, and physical filling.

02

Novi Orea Freeze-Dried Fibers: 100% Humanized Sequence

The humanized collagen used in the freeze-dried fibers is produced through a Pichia pastoris eukaryotic expression system. Compared with an Escherichia coli prokaryotic system, it offers a higher degree of humanization, stronger post-translational modification capabilities, and lower endotoxin levels. This makes it more compatible with human skin, supports bioidentical absorption with a lower risk of rejection, and substantially reduces the likelihood of allergic reactions.

Technically, the product uses a patented amino acid sequence (Patent No. ZL202310797546.3), with three segments comprising 410 amino acids from type III collagen recombined in tandem. Comparison against the NCBI database showed 100% homology. LC-ESI-MS/MS proteomic analysis further confirmed a 100% match with the designed amino acid sequence, achieving a genuinely 100% humanized sequence.

03

Multiple Benefits for Multi-Dimensional Anti-Aging Care

Firming and Wrinkle Reduction: In vitro studies show that Novi Orea freeze-dried fibers significantly promote COL1A1 (type I collagen) gene expression. At a concentration of 0.2%, relative mRNA expression reached 1.80, representing a 0.80-fold increase and effectively supporting type I collagen production.

Anti-Inflammatory and Sensitivity-Reducing Effects: The product regulates TNF-α gene expression in RAW264.7 cells and, compared with dexamethasone, demonstrates anti-inflammatory and sensitivity-reducing potential.

Intensive Repair: Cell-scratch assays show that recombinant humanized type III collagen significantly promotes human keratinocyte migration and accelerates repair. It also increases the number of cell layers and epidermal thickness, providing soothing and restorative support for compromised skin.

04

Broad Clinical Applications and Full-Face Treatment Options

Novi Orea Recombinant Collagen Freeze-Dried Fibers contain up to 80 mg per vial. Rich in highly purified humanized collagen freeze-dried fibers, the product supports efficient, multi-point anti-aging applications.

For clinical use, the product can be applied to multiple facial areas. For full-eye-area treatment, manual needle injection is recommended at depths of 0.5–1.0 mm in the dermis and 2–4 mm in the subcutaneous layer, with 0.01–0.05 mL per injection point, spacing of 1–3 mm, a 32G or 34G fine needle, and an injection angle of 20–70 degrees.

05

Contraindications and Post-Procedure Care

The product is not suitable for individuals who test positive for collagen sensitivity, including those with allergies to high-protein foods such as eggs or milk; people with a strong allergic predisposition; patients with autoimmune or connective-tissue diseases; or pregnant women.

After the procedure, apply a cold compress for 10 minutes. Normal face washing may resume after 12 hours and light makeup after 24 hours. For one week, avoid pressing or rubbing the treated area, high-temperature environments, direct sun exposure, smoking, alcohol, and spicy or irritating foods, and maintain a regular sleep schedule.

With patented extraction technology based on a 100% humanized sequence and multiple anti-aging benefits, the launch of Novi Orea Recombinant Collagen Freeze-Dried Fibers is expected to bring a compelling new option to the medical-aesthetics anti-aging market—offering consumers a safer, more effective rejuvenation solution with stronger value.